Melatonin Research Performed by Pharmasan Labs, Inc.

• A compromise phase position for permanent night shift workers: circadian phase after two night shifts with scheduled sleep and light/dark exposure. Lee C, Smith MR, Eastman CI. Chronobiol Int 2006;23:859-75. PMID: 16887753

• A late wake time phase delays the human dim light melatonin rhythm. Burgess HJ, Eastman CI. Neurosci Lett 2006;395:191-5. PMID: 16309837

• A three pulse phase response curve to three milligrams of melatonin in humans. Burgess HJ, Revell VL, Eastman CI. J Physiol 2008;586:639-47. PMID: 18006583

• Adaptation of human pineal melatonin suppression by recent photic history. Smith KA, Schoen MW, Czeisler CA. J Clin Endocrinol Metab 2004;89:3610-4. PMID: 15240654

• Advancing circadian rhythms before eastward fight: a strategy to prevent or reduce jet lag. Eastman CI, Gazda CJ, Burgess HJ, Crowley SJ, Fogg LF. Sleep 2005;28:33-44. PMID: 15700719

• Advancing human circadian rhythms with afternoon melatonin and morning intermittent bright light. Revell VL, Burgess HJ, Gazda CJ, Smith MR, Fogg LF, Eastman CI. J Clin Endocrinol Metab 2006;91:54-9. PMID: 16263827

• Binaural beat technology in humans: a pilot study to assess psychologic and physiologic effects. Wahbeh, H., Calabrese, C., and Zwickey, H. (2007) J.Altern.Complement Med. 13(1): 25-32. PMID: 17309374

• Circadian phase determined from melatonin profles is reproducible after 1 wk in subjects who sleep later on weekends. Revell VL, Kim H, Tseng CY, Crowley SJ, Eastman CI. J Pineal Res 2005;39:195-200. PMID: 16098098

• Combinations of bright light, scheduled dark, sunglasses, and melatonin to facilitate circadian entrainment to night shift work. Crowley SJ, Lee C, Tseng CY, Fogg LF, Eastman CI. J Biol Rhythms 2003;18:513-23. PMID: 14667152

• Complete or partial circadian re-entrainment improves performance, alertness, and mood during night-shift work. Crowley SJ, Lee C, Tseng CY, Fogg LF, Eastman CI. Sleep 2004;27:1077-87. PMID: 15532201

• Decreased sensitivity to phase-delaying effects of moderate intensity light in older subjects. Duffy JF, Zeitzer JM, Czeisler CA. Neurobiol Aging 2007;28:799-807. PMID: 16621166

• The dim light melatonin onset following fxed and free sleep schedules. Burgess HJ, Eastman CI. J Sleep Res 2005;14:229-37. PMID: 16120097

• Early versus late bedtimes phase shift the human dim light melatonin rhythm despite a fxed morning lights on time. Burgess HJ, Eastman CI. Neurosci Lett 2004;356:115-8. PMID: 14746877

• Effcacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans. Gronfer C, Wright KP, Jr., Kronauer RE, Jewett ME, Czeisler CA. Am J Physiol Endocrinol Metab 2004;287:E174-E181. PMID: 15039146

• Exercise distributed across day and night does not alter circadian period in humans. Cain SW, Rimmer DW, Duffy JF, Czeisler CA. J Biol Rhythms 2007;22:534-41. PMID: 15039146

• The impact of sleep timing and bright light exposure on attentional impairment during night work. Santhi N, Aeschbach D, Horowitz TS, Czeisler CA. J Biol Rhythms 2008;23:341-52. PMID: 18663241

• Individual differences in the amount and timing of salivary melatonin secretion. Burgess HJ, Fogg LF. PLoS ONE 2008;3:e3055. PMID: 18725972

• Phototransduction for human melatonin suppression. Rea MS, Bullough JD, Figueiro MG. J Pineal Res 2002;32:209-13. PMID: 11982788

• Plasticity of the intrinsic period of the human circadian timing system. Scheer FA, Wright KP, Jr., Kronauer RE, Czeisler CA. PLoS ONE 2007;2:e721. PMID: 17684566

• Prefight adjustment to eastward travel: 3 days of advancing sleep with and without morning bright light. Burgess HJ, Crowley SJ, Gazda CJ, Fogg LF, Eastman CI. J Biol Rhythms 2003;18:318-28. PMID: 12932084

• Regulation of central dopamine-2 receptor sensitivity by a proportional control thermostat in humans. Schwartz PJ, Erk SD. Psychiatry Res 2004;127:19-26. PMID: 15261701

• Shaping the light/dark pattern for circadian adaptation to night shift work. Smith MR, Cullnan EE, Eastman CI. Physiol Behav 2008;95:449-56. PMID: 18675836

• Short nights attenuate light-induced circadian phase advances in humans. Burgess HJ, Eastman CI. J Clin Endocrinol Metab 2005;90:4437-40. PMID: 15886231

• Sleep- and circadian-dependent modulation of REM density. Khalsa SB, Conroy DA, Duffy JF, Czeisler CA, Dijk DJ. J Sleep Res 2002;11:53-9. PMID: 11869427

• Sleep logs of young adults with self-selected sleep times predict the dim light melatonin onset. Martin SK, Eastman CI. Chronobiol Int 2002;19:695-707. PMID: 12182497

• The validity and feasibility of saliva melatonin assessment in the elderly. Gooneratne NS, Metlay JP, Guo W, Pack FM, Kapoor S, Pack AI. J Pineal Res 2003;34:88-94. PMID 12562499